White Wolf of Icicle Creek is the sixteenth installment in the Nancy Drew computer game series. Nancy Drew travels to the Canadian Rockies to investigate the Icicle Creek Lodge. Chantal, the owner of the lodge has asked her to uncover the culprit behind a recent string of suspicious accidents. To make matters worse, an eerie howling wolf keeps everyone up at night and terrorizes the guests.

The wolf also appears at the site of accidents and then mysteriously disappears when the police arrive. As Nancy makes her way to the cozy lodge, an explosion rocks the quiet night, destroying a bunkhouse. A wolf howls mournfully in the distance. Nancy has barely set foot on the premise and already trouble is afoot! Can Nancy solve this mystery before all the guests leave and Chantal is left out in the cold?